01 - Preheat oven to 400°F. Lightly grease a 9×13 inch baking dish with olive oil or cooking spray.
02 - In a small bowl, combine the chili powder, smoked paprika, cumin, garlic powder, onion powder, salt, and black pepper. Mix thoroughly and set aside.
03 - Place each chicken breast between two sheets of plastic wrap and pound with a meat mallet to approximately ⅜ inch uniform thickness.
04 - Drizzle the flattened chicken breasts with 1 tablespoon of olive oil, then evenly sprinkle half of the seasoning blend over both sides of each breast.
05 - Heat the remaining 1 tablespoon of olive oil in a large skillet over medium heat. Add the sliced red and yellow bell peppers along with the red onion. Sauté for 3 to 4 minutes until just tender but still slightly crisp. Remove from heat and toss with the remaining seasoning blend.
06 - Lay each seasoned chicken breast flat. Distribute the sautéed pepper and onion mixture evenly across each breast, then sprinkle generously with the shredded cheese.
07 - Roll each chicken breast up tightly, starting from one end. Secure each roll with 2 to 3 toothpicks to hold its shape. Place the rolls seam side down in the prepared baking dish.
08 - Bake in the preheated oven for 25 to 30 minutes, or until the internal temperature of the chicken reaches 165°F and the juices run clear.
09 - Remove from the oven and let the roll ups rest for 5 minutes. Carefully remove the toothpicks, slice each roll into pinwheels, and garnish with fresh cilantro and lime wedges before serving.